Human epidermal growth factor receptor type 3 (HER3) is recognized to be involved in resistance to HER-targeting therapies. A number of HER3-targeting monoclonal antibodies are under clinical investigation as potential cancer therapeutics. Smaller high-affinity scaffold proteins are attractive non-Fc containing alternatives to antibodies. A previous study indicated that anti-HER3 affibody

Affibody AB (“Affibody”) and Inmagene Biopharmaceuticals (“Inmagene”) today announced that the U.S. FDA has cleared the novel interleukin-17 (IL-17) blocker izokibep (ABY-035) to proceed

Initial results confirm compound to be safe and well-tolerated across all doses in healthy volunteers. Affibody: ClinicalTrials.gov Identifier: NCT04706741 Other Study ID Numbers: ABY-035-203 : First Posted: January 13, 2021 Key Record Dates: Last Update Posted: January 19, 2021 Last Verified: December 2020 Affibody AB (“Affibody”), a clinical stage biopharmaceutical company, today announced the initiation of its 52-week trial investigating the novel bispecific IL-17A inhibitor ABY-035 in Affibody: ClinicalTrials.gov Identifier: NCT03591887 Other Study ID Numbers: ABY-035-002 2017-001615-36 ( EudraCT Number ) First Posted: July 19, 2018 Key Record Dates: Last Update Posted: July 10, 2020 Last Verified: July 2020 Individual Participant … Affibody AB (“Affibody”) today announced that it has completed the dose-escalation part of a Phase I study of ABY-035, which is the company’s proprietary psoriasis program. Initial results confirm compound to be safe and well-tolerated across all doses in healthy volunteers. Affibody Announces Interim Analysis in Phase 2 Psoriasis Trial of ABY-035 Pressmeddelande • Jul 16, 2019 16:00 CEST Solna, Sweden, July 16, 2019. Affibody Announces Interim Analysis in Phase 2 Psoriasis Trial of ABY-035 ons, jul 17, 2019 09:16 CET. Solna, Sweden, July 16, 2019. Affibody AB (“Affibody”), a clinical stage biopharmaceutical company developing a pipeline of innovative drug projects, today announced the completion of the planned 12 week interim analysis in the Company’s Phase 2 proof-of-concept study of its bispecific Affibody, a clinical stage biopharmaceutical company, today announced positive top-line data from its 52-week trial investigating the novel bispecific IL-17A inhibitor ABY-035 in patients with moderate-to-severe psoriasis (“AFFIRM-35”).

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Notable examples include (in alphabetical order)Affibody® (Affibody), Affimer® (Avacta), Anticalin® (Pieris Pharmaceuticals), Adnectin TM (BMS), Bicycles® (Bicycle Therapeutics), DARPin® (Molecular Partners), Kunitz Domain (Shire) and Nanofitin® (Affilogic). 2017-08-01 Human epidermal growth factor receptor type 3 (HER3) is recognized to be involved in resistance to HER-targeting therapies. A number of HER3-targeting monoclonal antibodies are under clinical investigation as potential cancer therapeutics. Smaller high-affinity scaffold proteins are attractive non-Fc containing alternatives to antibodies. A previous study indicated that anti-HER3 affibody Inmagene and Affibody have formed a strategic partnership to develop and commercialize izokebep (IMG-020 or ABY-035), a bispecific fusion protein targeting Interleukin-17A, for multiple auto-immune indications worldwide. Solna, Sweden, June 15, 2020. Affibody AB (“Affibody”), a clinical stage biopharmaceutical company, today announced positive top-line data from its 52-week trial investigating the novel bispecific IL-17A inhibitor ABY-035 in patients with moderate-to-severe psoriasis (“AFFIRM-35”).

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ABY-035 / AFB-035 (Affibody). 6.7. MP0250 ( Molecular Partners).

Affibody AB (“Affibody”), a clinical stage biopharmaceutical company, today announced the initiation of its 52-week trial investigating the novel bispecific IL-17A inhibitor ABY-035 in

Since their introduction 20 years ago as an alternative to antibodies for biotechnological applications, the first therapeutic affibody molecules have now entered clinical development and more than 400 studies have been published in which affibody molecules have been developed and used in a Jun 15, 2020 Overall, ABY-035 treatment appeared tolerable and safe. “Our Phase 2 AFFIRM- 35 trial in patients with moderate-to-severe psoriasis has Feb 10, 2021 Affibody AB (“Affibody”) and Inmagene Biopharmaceuticals (ABY-035) to proceed to Phase 2 clinical development in Ankylosing Spondylitis ABY-035 is a novel molecule, which is being developed with an aim to help people with psoriasis. ABY-035 acts by blocking interleukin IL-17A. IL-17A is thought to Mar 20, 2021 PDF | Affibody molecules can be used as tools for molecular recognition in and the molecule was named ABY-035 and has entered clinical. Feb 15, 2021 “Working closely with our partner Affibody, the Inmagene team is Also called IMG-020 andABY-035, izokibep is an engineered protein. Jan 20, 2020 pharmacokinetics and immunogenicity of ABY-035 B.4.1, Name of organisation providing support, Affibody AB. B.4.2, Country, Sweden. Inmagene and Affibody have formed a strategic partnership to develop and commercialize izokebep (IMG-020 or ABY-035), a bispecific fusion protein targeting NASDAQ:IMAB).

ABY-035 is a novel IL-17A targeting agent that utilizes the strengths of Affibody’s technology platform to create a very small protein drug (18 kDa, an eighth of an antibody) with very high apparent affinity to IL-17A (KD ~300fM) and antibody-like half-life. Affibody and Inmagene announce IND Clearance for izokibep (ABY-035) for the treatment of Non-infectious Non-anterior Uveitis San Diego, U.S., Shanghai, China, and Solna, Sweden, March 9, 2021. Affibody AB (“Affibody”) and Inmagene Biopharmaceuticals (“Inmagene”) today announced that the U.S. FDA [read more] 2021-02-19 ABY-035 is a novel bispecific agent, potently targeting both subunits of IL-17A as well as albumin, which has been specifically designed to utilize the strengths of Affibody’s technology platform to create a very small protein drug (18 kDa, an eighth of the size of an antibody) with very high apparent affinity to IL-17A (KD ~300fM) and antibody-like half-life due to the strong (KD ~50pM) binding affinity to serum albumin. Affibody AB (“Affibody”) and Inmagene Biopharmaceuticals (“Inmagene”) today announced that the U.S. FDA has cleared izokibep (ABY-035) to proceed to Phase 2 clinical development in Ankylosing Spondylitis (AS), a subset of Axial Spondyloarthritis (axSpA). ABY-035 is a novel IL-17A targeting agent that utilizes the strengths of Affibody’s technology platform to create a very small protein drug (18 kDa, an eighth of an antibody) with very high apparent affinity to IL-17A (KD ~300fM) and antibody-like half-life. ABY-035 is a novel bispecific agent potently targeting both subunits of IL-17A as well as albumin (both targets being prevalent in psoriatic skin) which has been specifically designed to utilize the strengths of Affibody’s technology platform to create a very small protein drug (18 kDa, an eighth of the size of an antibody) with very high apparent affinity to IL-17A (KD ~300fM) and antibody-like half-life. ABY-035 has been specifically designed to utilize the strengths of Affibody’s technology platform to create a very small protein drug (18 kDa, an eighth of the size of an antibody) with very high apparent affinity to IL-17A (KD ~300fM) and antibody-like half-life due to the strong (KD ~50pM) binding affinity to serum albumin.
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Affibody AB (“Affibody”) today announced that it has decided to initiate Phase II development with ABY-035, which is the company’s proprietary psoriasis program.

An interesting case is an Affibody molecule specific for the amyloid-β (Aβ) peptide involved in Alzheimer’s disease [72] . Affibody将负责为ABY-035在全球的临床开发和商业化进行药品的生产和供应。 ABY-035是抑制白介素17的新型融合蛋白药物，即将完成全球临床二期。ABY-035利用Affibody独创的、具有全球专利的两大技术平台 “Affibody技术平台” 和 “Albumod技术平台” 开发而成。 Affibody molecules can be engineered in different formats. (a) and the molecule wa s named ABY-035 and ha s entered clinic al.
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Affibody announces that it has decided to initiate Phase II development with ABY-035, which is the company’s proprietary psoriasis program. “This Affibody molecule, ABY-035, has been specifically designed to capture the unique aspects of the Affibody technology. It is a bi-specific construct with extraordinary affinity and confirmed antibody-like half-life. The initial results from our

That construct is coupled to a third component, Albumod, Affibody’s small albumin-binding domain, which extends the molecule’s half-life. “ABY-035 is a unique multivalent and bispecific molecule, targeting both subunits of IL-17 as well as albumin and the Phase 2 AFFIRM-35 study is designed to take full advantage of the strengths of the dual targeting ABY-035. Affibody, a clinical stage biopharmaceutical company, today announced positive top-line data from its 52-week trial investigating the novel bispecific IL-17A inhibitor ABY-035 in patients with moderate-to-severe psoriasis (“AFFIRM-35”).