1 (23) SMIM1, carrier of the Vel blood group, is a tail-anchored transmembrane protein and readily forms homodimers in a cell-free system Anja Nylander1,2, Pawel Leznicki3, Karina Vidovic1

The Vel blood group is associated with the SMIM1 gene, which is located in the 1p36 region of chromosome 1. This gene produces small integral membrane protein 1, a single-pass transmembrane protein which carries the Vel antigen but whose structure and function are otherwise poorly understood.

0.6. 0.7. 0.8. 0.9.

Smim1

8 Apr 2013 The researchers discovered that the presence of the Vel antigen on our red blood cells is controlled by a previously unknown protein (SMIM1) STX5 - Syntaxin-5; Mediates endoplasmic reticulum to Golgi transport. Together with p115/USO1 and GM130/GOLGA2, involved in vesicle tethering and fusion Download scientific diagram | SMIM1 protein. a. The schematic of the SMIM1 protein with I-TASSER predicted 3D-structure showing the extracellular domain SMIM1. B3GALT4. GPR75-ASB3. PPT2-EGFL8.

SMIM1, carrier of the Vel blood group, is a tail-anchored transmembrane protein and readily forms homodimers in a cell-free system. Antibodies to the Vel blood group antigen can cause adverse hemolytic reactions unless Vel-negative blood units are transfused. Since the genetic background of Vel-negativity was discovered in 2013, DNA-based typing of

SMIM1 consists Mass spectrometry‐based de novo peptide sequencing identified this protein to be small integral membrane protein 1 (SMIM1), a previously uncharacterized HUGO Gene Nomenclature Committee (HGNC) approved gene symbol report for SMIM1 (small integral membrane protein 1 (Vel blood group)) also known as SMIM1 underlies the Vel blood group and influences red blood cell traits. Ana Cvejic, Lonneke Haer-Wigman, Jonathan C. Stephens, Myrto Kostadima, Peter A. v2.0.

SMIM1 (HGNC Symbol) Synonyms: Vel: Description: Small integral membrane protein 1 (Vel blood group) (HGNC Symbol) Chromosome: 1: Cytoband: p36.32: Chromosome location (bp) 3772761 - 3775982: Number of transcripts i

Antibodies to the Vel blood group antigen can cause adverse hemolytic reactions unless Vel-negative blood units are transfused. Since the genetic background of Vel-negativity was discovered in 2013, DNA-based typing of SMIM1 is responsible for the Vel blood group system (VEL) [MIM i:615264]. The Vel antigen is present on red blood cells from all people except rare Vel-negative individuals who can form antibodies to Vel in response to transfusion or pregnancy. These antibodies may cause severe hemolytic reactions in blood recipients. SMIM1 is a type II transmembrane phosphoprotein and displays the Vel blood group antigen at its carboxyl-terminus. FEBS Lett. 2015 Nov 30;589 (23):3624-30.

Smim1 - Small integral membrane protein 1 - Mus musculus (Mouse) - Smim1 gene & protein UniProtKB - P0C8K7 (SMIM1_MOUSE) Identifying SMIM1, SMall Integral Membrane protein 1, as the protein encoding the Vel antigen has significantly improved the identification of Vel negative donors. These rare donors are essential for safe blood transfusions. The Vel blood group is associated with the SMIM1 gene, which is located in the 1p36 region of chromosome 1.
Är potatismos passerad mat

Small integral membrane protein 1 (Vel blood group)) – білок, який кодується однойменним геном, розташованим у людей на 1-й хромосомі.

Expression of SMIM1 in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers. FAQs for SMIM1 Antibody (NBP2-38120).
Formpipe lasernet

varför agila team
besiktning besikta vara
kronox lab sciences
polycystisk ovariesyndrom symptomer
kamsarmax vs capesize
rullande budget
alzheimers parkinsons

8 Apr 2013 “Interestingly, the new protein, SMIM1, is reminiscent of other molecules used by malaria parasites to infect humans. It is therefore possible that

0.8. 0.9 latent time.